Combine meat, salt, pepper, onion powder, and garlic powder in a medium bowl. Form into 4 patties, about half an inch thick. Make a small indent in the middle of the patty with your thumb. Brush patties with your favorite barbecue sauce. Preheat the air fryer to 370°F. Add patties in a single layer to the basket. Cook 6 minutes. Flip burger over and cook an additional 3-5 minutes or until beef reaches 160°F. Add cheese if using and cook 1 minute more. Serve on fresh hamburger buns from the bakery. Enjoy!